Answer
No, English alone is usually not enough: it does not guarantee employment in Uruguay. Without knowledge of the official language, it is impossible to apply for the vast majority of local vacancies.
English can help in international companies, remote work, and particular professional niches, but it does not replace Spanish in a regular work environment. Most communication with employers, colleagues, and clients takes place in the local language.
Therefore, English is best considered an advantage in addition to Spanish, rather than a substitute for it. For a real job search, you need a résumé, an interview, an understanding of the contract, and the ability to explain your tasks in Spanish at least at a working level, without the constant help of a translator.