Answer
Intercity buses are the main practical way to travel between major Uruguayan cities without a car. On popular routes, regular services, luggage compartments, and easy-to-navigate terminals are usually available. However, the level of comfort, the number of stops, and the journey time depend on the carrier and the specific type of service.
For personal safety, the usual rules apply: buy a ticket from the carrier or at an official ticket office, keep the luggage receipt, and do not leave documents or electronics in checked luggage. At an intermediate stop, confirm the departure time and do not go far from the bus.
For an important connection, choose a service with extra time to spare, especially during holidays and high season. Before departure, check the arrival terminal: it may not be close to your accommodation, and the final leg may require walking or taking a local bus or taxi.